パラミクソウイルス（ムンプスウイルスなど）の細胞内での増殖に関与する宿主因子を見つけ出し、それらとウイルス因子との関係を解析することで、パラミクソウイルスのRNA合成や粒子形成機構の解明を目指しています。これまでに、ムンプスウイルスのRNAポリメラーゼとシャペロンタンパク質（Hsp70やHsp90）との関連、SNAREタンパク質とウイルス糖タンパク質の糖鎖修飾との関連などを明らかにしてきました。さらに、現在もさまざまな宿主因子の解析を行っています

主な関連業績

1. Yasukochi M, Hosogi M, Kitai Y, Akahori Y, Ryo A, Takeda M, Katoh H. Coordinated interactions among Nipah virus N, P, and M proteins drive formation of distinct inclusion bodies. J Gen Virol. Accepted.
2. Okura T, Nakai Y, Kameya T, Mizukoshi F, Okura H, Kakizaki M, Kato F, Matsumoto Y, Nakatsu Y, Takeuchi K, Kimura H, Takeda M, Otsuki N, Hasegawa H, Shirato K, Ryo A. Paramyxovirus matrix protein redirects METTL3 to modulate m6A epitranscriptomics and host innate immune response. PLOS Pathogens. Published.
3. Katoh H, Kimura R, Sekizuka T, Matsuoka K, Hosogi M, Kitai Y, Akahori Y, Kato F, Kataoka M, Kobayashi H, Nagata N, Suzuki T, Ohkawa Y, Oki S, Takeda M. Structural and molecular properties of mumps virus inclusion bodies. Sci Adv. 2024 Dec 6;10(49):eadr0359. doi: 10.1126/sciadv.adr0359. Epub 2024 Dec 6. PMID: 39642233; PMCID: PMC11623304.
4. Liu Y, Katoh H, Sekizuka T, Bae C, Wakata A, Kato F, Sakata M, Yamaji T, Wang Z, Takeda M. SNARE protein USE1 is involved in the glycosylation and the expression of mumps virus fusion protein and important for viral propagation. PLoS Pathog. 2022 Dec 8;18(12):e1010949. doi: 10.1371/journal.ppat.1010949. PMID: 36480520; PMCID: PMC9731409.
5. Wakata A, Katoh H, Kato F, Takeda M. Nucleolar Protein Treacle Is Important for the Efficient Growth of Mumps Virus. J Virol. 2022 Oct 12;96(19):e0072222. doi: 10.1128/jvi.00722-22. Epub 2022 Sep 22. PMID: 36135364; PMCID: PMC9555161.
6. Katoh H, Sekizuka T, Nakatsu Y, Nakagawa R, Nao N, Sakata M, Kato F, Kuroda M, Kidokoro M, Takeda M. The R2TP complex regulates paramyxovirus RNA synthesis. PLoS Pathog. 2019 May 23;15(5):e1007749. doi: 10.1371/journal.ppat.1007749. PMID: 31121004; PMCID: PMC6532945.
7. Katoh H, Kubota T, Nakatsu Y, Tahara M, Kidokoro M, Takeda M. Heat Shock Protein 90 Ensures Efficient Mumps Virus Replication by Assisting with Viral Polymerase Complex Formation. J Virol. 2017 Feb 28;91(6):e02220-16. doi: 10.1128/JVI.02220-16. PMID: 28053100; PMCID: PMC5331814.
8. Katoh H, Kubota T, Kita S, Nakatsu Y, Aoki N, Mori Y, Maenaka K, Takeda M, Kidokoro M. Heat shock protein 70 regulates degradation of the mumps virus phosphoprotein via the ubiquitin-proteasome pathway. J Virol. 2015 Mar;89(6):3188-99. doi: 10.1128/JVI.03343-14. Epub 2014 Dec 31. PMID: 25552722; PMCID: PMC4337538.